Incremental Data Change for Curated Data Repository Version 9 - Genomic Data

As of August 14, 2026, we’re excited to announce the release of the following auxiliary genomic files for CDR v9 Controlled Tier data. These data are now available in the Researcher Workbench. The new data now includes:

• Mitochondrial variant calling
• Phasing data
• Genetic admixture
• Long-read haplotagged BAMs
• Long-read per-sample methylation calls

You can learn more about the multi-omic data here:

• All of Us Genomics & Multi-omics Quality Report
• How the All of Us Genomic and mulit-omics data are organized

Additionally, two quality issues were resolved for  the existing genomics dataset as part of this release. 

Background

The two new issues have been documented in the All of Us Genomics & Multi-omics Quality Report and are referred to as Known Issues #7 and #8. 

Known Issue #7 Incomplete MANE annotations in VAT

Due to a workflow processing issue, the Variant Annotation Table (VAT) was missing Matched Annotation from the NCBI and EMBL-EBI (MANE) annotations. Specifically, only ~6% of the transcripts that should have received MANE annotations were annotated. This was remediated August 14, 2026. 

The Researcher Workbench team released an update for the v9 Curated Data Repository (CDR) short-read whole genome sequencing (srWGS) Variant Annotation Table (VAT) to ensure consistency with data quality procedures. 

For detailed information and recommended actions, read the All of Us Genomics & Multi-omics Quality Report, Known Issue #7.  
 

Known Issue #8 Samples were impacted by a data quality issue (N=7)

Seven participant IDs in the srWGS CDRv9 data release are affected by a data quality issue and each of these participants have srWGS and array data. A file containing the affected research IDs is available in the Researcher Workbench (RW). srWGS SV, long-read, RNA Sequencing, and Proteomics samples are not impacted.

The samples will be removed in the next major release (CDRv10), researchers should remove the affected samples from analysis. A list of research IDs of affected samples in the CDR can be found in the Data Dictionary.

If you have any questions, please contact our support team at support@researchallofus.org.