On June 26, 2026, the All of Us Research Program released the genomic and multi-omic data of 553,949 array samples, 535,662 srWGS samples with SNP & Indel calls, 96,405 srWGS samples with SV calls, 8,980 RNA Seq samples, 9,969 proteomics samples and 14,521 lrWGS samples in the Researcher Workbench (RW) for use by researchers registered for Controlled Tier access. As described previously [2], this high-quality genetic data along with comprehensive health data will enable health research and catalog the genetic variation that leads to human health and disease. For a snapshot of the data, see Table 1.
| Dataset | Number of participants | Highlights |
| Array | 553,949 |
|
| Short-read WGS SNP and Indel | 535,662 |
|
| Short-read WGS structural variants (SVs) | 96,405 |
|
| Long-read WGS | 14,521 |
|
| RNA Seq | 8,980 |
|
| Proteomic samples | 9,969 |
|
In addition to variant calls, raw data (IDAT files for array data, CRAM files for srWGS data, BAM files for lrWGS data and RNA data), and auxiliary files (including variant annotations, pharmacogenomics, genetic ancestry categories, relatedness/kinship scores, HLA variant calls, and challenging medically relevant gene calls) are available in the RW through Controlled Tier access. Quality control processes, performed both independently and across samples, indicate that these data are ready for general analysis. We suggest researchers, at a minimum, read the Known Issues and FAQ sections below before using the data.
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