Leverage America’s Health Research Platform to Advance Bold, Innovative Research

Introduction:

Are you supporting health sciences research that would benefit from vast data collected from hundreds of thousands of participants across the United States? Encourage researchers you work with to leverage data from the National Institutes of Health’s All of Us Research Program.

The All of Us Researcher Workbench makes available one of the largest, most comprehensive datasets of its kind for broad use to support thousands of studies on health and disease. Today, more than 1,000 institutions have data use agreements to use this vast existing data source rather than relying on new, large-scale data collection efforts. This ensures sustainability, feasibility, and replicability of research efforts. The text below can be used to describe the All of Us dataset to the researchers you work with.

For additional information about the program, please refer directly to the All of Us website, including the All of Us Protocols.

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About the All of Us Research Program

The All of Us Research Program is a historic effort to gather data and biospecimens from at least 1 million people living in the United States, with the goal of accelerating research and medical breakthroughs and enabling individualized prevention, treatment, and care.

All of Us serves as a national research resource to inform thousands of studies, covering a wide range of health conditions. Researchers use data from the program to learn more about how individual differences in lifestyle, environment, and genetics can influence health and disease.

The dataset is refreshed regularly and available to registered researchers. It currently includes:

• Survey responses from more than 633,000 participants, capturing data on health history, lifestyle, health care access, and more;
• Short-read whole genome sequence data from more than 414,000 participants;
• More than 1.2 billion genetic variants, including more than 200 million previously unreported genetic variants;
• Electronic health record data shared by more than 393,000 participants (including demographics, visits, diagnoses, and medications);
• Fitbit data shared by more than 59,000 participants; and
• Physical measurements shared by more than 509,000 participants (including blood pressure, heart rate, BMI, and more).

About the Researcher Workbench

The All of Us data are housed on a centralized, cloud-based platform for analysis, the Researcher Workbench. Researchers affiliated with organizations with a Data Use and Registration Agreement can register to use the Researcher Workbench by verifying their identity, signing a Data User Code of Conduct, and completing required All of Us training on conducting research ethically and responsibly and preventing misuse of participant data.

The dataset is free to access, although researchers may be responsible to pay for computational resources and storage fees. Once registered to use the Researcher Workbench, researchers can create workspaces without project pre-approval.

Beyond the robust data resource, the Researcher Workbench helps accelerate research through tools such as collaborative workspaces, cohort-building tools, interactive notebooks, and more. Additional personalized support resources are also available, such as an integrated help desk, regular office hours, sample datasets, and more.

Visit ResearchAllofUs.org for more details about All of Us resources and access and use the All of Us Data Browser to find the most up to date data that researchers can use today.