A Researcher’s Guide to the All of Us Research Program

Researchers should read the guide to understand the strengths, weaknesses, and nuances of the All of Us dataset before developing methods to answer their scientific questions and interpret their results. This will help avoid errors in methodology and data use.

This guide provides background information on the program’s experimental design and execution, participant eligibility, enrollment procedures, and more.

How to use this document

• Researchers who are new to All of Us data should start at the history section, paying special attention to program design and participant recruitment.
• Researchers who plan to use demographic details, including self-identified race and ethnicity, should review the participant characteristics section prior to designing a study to understand key factors relating to data completeness, accuracy, and generalizability.
• Researchers who are already familiar with program basics and the statistical challenges of large cohort studies outlined above can start with this article on relevant data types for their intended studies and then explore the unique characteristics of each further in the guide.

• All of Us - A Researcher's Guide.pdf5 MB